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Int J Hematol. 2014 Oct;100(4):402-6. doi: 10.1007/s12185-014-1610-2. Epub 2014 Jun 18.

HIV-related NK/T-cell lymphoma in the brain relapsed during intensive chemotherapy but regressed after chemotherapy discontinuation: the importance of maintaining cellular immunity.

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  • 1Department of Hematology, Kobe City Medical Center General Hospital, 2-1-1 Minami-Machi Minatojima, Chuo-Ku, Kobe, 650-047, Japan,


This study reports a case of human immunodeficiency virus (HIV)-related natural killer/T-cell lymphoma with an unexpected clinical course. The lymphoma cells were positive for Epstein-Barr virus and the primary nodal lesions regressed after chemotherapy and combined antiretroviral therapy (c-ART); however, brain metastasis progressed along with a reduction in the CD8+ T-cell count. Chemotherapy was discontinued and the patient was treated with c-ART alone, resulting in regression of the brain lesions and recovery of the CD8+ T-cell count. This case highlights the importance of maintaining anti-tumor immunity in patients with HIV-related lymphoma.

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