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J Clin Invest. 2014 Jul;124(7):2844-6. doi: 10.1172/JCI76630. Epub 2014 Jun 17.

Kidney α-intercalated cells and lipocalin 2: defending the urinary tract.

Abstract

A growing body of evidence indicates that the kidneys contribute substantially to immune defense against pathogens in the urinary tract. In this issue, Paragas et al. report that α-intercalated cells (A-ICs) within the nephron collecting duct sense infecting Gram-negative bacteria, resulting in simultaneously secretion of the iron chelating protein lipocalin 2 (LCN2) and protons, which acidify the urine. A-IC-specific LCN2 and proton secretion markedly reduced the ability of infecting uropathogenic E. coli (UPEC) to grow and sustain infection. The capacity of A-ICs to sense and actively promote clearance of infecting bacteria in the lower urinary tract represents a novel function for these specialized kidney cells, which are best known for their role in modulating acid-base homeostasis.

PMID:
24937424
PMCID:
PMC4071399
DOI:
10.1172/JCI76630
[Indexed for MEDLINE]
Free PMC Article

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