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J Clin Invest. 2014 Jul;124(7):2846-8. doi: 10.1172/JCI76626. Epub 2014 Jun 17.

Loss of P2Y₁₄ results in an arresting response to hematological stress.

Abstract

The regenerative capacity of tissues to recover from injury or stress is dependent on stem cell competence, yet the underlying mechanisms that govern how stem cells detect stress and initiate appropriate responses are poorly understood. In this issue of the JCI, Cho and Yusuf et al. demonstrate that the purinergic receptor P2Y14 may mediate the hematopoietic stem and progenitor cell regenerative response.

PMID:
24937422
PMCID:
PMC4071389
DOI:
10.1172/JCI76626
[Indexed for MEDLINE]
Free PMC Article

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