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Curr Opin Neurobiol. 2014 Dec;29:57-63. doi: 10.1016/j.conb.2014.05.008. Epub 2014 Jun 14.

Feeding regulation in Drosophila.

Author information

1
Department of Molecular and Cell Biology, and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, United States.
2
Department of Molecular and Cell Biology, and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, United States; Howard Hughes Medical Institute, 16 Barker Hall, University of California, Berkeley, Berkeley, CA 94720, United States. Electronic address: kscott@berkeley.edu.

Abstract

Neuromodulators play a key role in adjusting animal behavior based on environmental cues and internal needs. Here, we review the regulation of Drosophila feeding behavior to illustrate how neuromodulators achieve behavioral plasticity. Recent studies have made rapid progress in determining molecular and cellular mechanisms that translate the metabolic needs of the fly into changes in neuroendocrine and neuromodulatory states. These neuromodulators in turn promote or inhibit discrete feeding behavioral subprograms. This review highlights the links between physiological needs, neuromodulatory states, and feeding decisions.

PMID:
24937262
PMCID:
PMC4253568
DOI:
10.1016/j.conb.2014.05.008
[Indexed for MEDLINE]
Free PMC Article

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