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Biosci Microbiota Food Health. 2012;31(4):103-8. doi: 10.12938/bmfh.31.103. Epub 2012 Oct 25.

Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats.

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Nayoro City University, Kita 8-1, Nishi 4, Nayoro, Hokkaido 096-8641, Japan.
Luminacoid Laboratory, Mure 4-1-4, Mitaka, Tokyo 181-0002, Japan.


We examined whether feeding high hydrogen generating resistant starch could suppress subacute hepatic ischemia-reperfusion injury. Rats were fed a control diet with or without 20% high amylose cornstarch (HAS) supplementation for 14 days. On day 12, rats were subject to ischemia-reperfusion treatment. Portal hydrogen concentration was higher in the HAS group compared with the control group. Increased plasma alanine and aspartate aminotransferase activities due to ischemia-reperfusion treatment tended to decrease, and a significant reduction was observed by HAS feeding when compared with the control group. In conclusion, HAS, which enhances hydrogen generation in the hindgut, alleviated subacute hepatic ischemia-reperfusion injury.


antioxidant; high amylose cornstarch; hydrogen; ischemia-reperfusion; large intestine

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