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World J Gastrointest Oncol. 2014 Jun 15;6(6):170-6. doi: 10.4251/wjgo.v6.i6.170.

Monoclonal antibodies that target the immunogenic proteins expressed in colorectal cancer.

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1
Myron Arlen, Gene Coppa, Jim Crawford, Ernesto Molmenti, Department of Surgery, Division of Surgical Oncology and the Dept. of Pathology, North Shore University Hospital, Manhasset, NY 11030, United States.

Abstract

In an attempt to improve upon the end results obtained in treating colorectal cancer it was apparent that the earlier the diagnosis that could be obtained, the better the chance for obtaining desired results. In the case of more advanced tumors typified by later stage colorectal cancer, surgical debulking is an important part of the treatment strategy. Here the use of additional therapeutic modalities including chemotherapy and present day immunotherapy has failed to accomplish the desired improvements that have been sought after. Adjuvant therapy, has offered little to the overall survival. The concept of early detection is now recognized as the initial step in reaching proper end results and can readily be demonstrated from colorectal cancer studies. Here survival has been found to be a reflection of the stage at which the tumor is first identified and treated. When specific monoclonals targeting colorectal cancer are employed diagnostically, we have been able to demonstrate detection of colorectal cancer at its inception as a premalignant lesion, such that genotypic features can be identified before the phenotypic appearance of cancer can be noted.

KEYWORDS:

Antibody dependent cell cytotoxicity; Colorectal cancer; Immunohistochemistry; Monoclonal antibodies; Tumor associated antigens

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