Format

Send to

Choose Destination
See comment in PubMed Commons below
Hypertension. 2014 Sep;64(3):494-500. doi: 10.1161/HYPERTENSIONAHA.114.03545. Epub 2014 Jun 16.

Ambient air pollution and pregnancy-induced hypertensive disorders: a systematic review and meta-analysis.

Author information

1
From the Centre for Research in Environmental Epidemiology, Barcelona, Spain (M.P., L.S., M.J.N., P.D.); CIBER Epidemiología y Salud Pública, Madrid, Spain (M.P., M.J.N., P.D.); Universitat Pompeu Fabra, Barcelona, Spain (M.P., M.J.N., P.D.); INSERM, U823, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute Albert Bonniot, Grenoble, France (M.P., R.S.); Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago (L.S.); University Joseph Fourier, Institute Albert Bonniot, Grenoble, France (R.S.); Danish Cancer Society Research Center, Copenhagen, Denmark (M.S., O.R.-N.); and Department of Maternal-Foetal Medicine, ICGON, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain (F.F.). mpedersen@creal.cat.
2
From the Centre for Research in Environmental Epidemiology, Barcelona, Spain (M.P., L.S., M.J.N., P.D.); CIBER Epidemiología y Salud Pública, Madrid, Spain (M.P., M.J.N., P.D.); Universitat Pompeu Fabra, Barcelona, Spain (M.P., M.J.N., P.D.); INSERM, U823, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute Albert Bonniot, Grenoble, France (M.P., R.S.); Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago (L.S.); University Joseph Fourier, Institute Albert Bonniot, Grenoble, France (R.S.); Danish Cancer Society Research Center, Copenhagen, Denmark (M.S., O.R.-N.); and Department of Maternal-Foetal Medicine, ICGON, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain (F.F.).

Erratum in

  • Hypertension. 2015 Jan;65(1):e1-6.

Abstract

Pregnancy-induced hypertensive disorders can lead to maternal and perinatal morbidity and mortality, but the cause of these conditions is not well understood. We have systematically reviewed and performed a meta-analysis of epidemiological studies investigating the association between exposure to ambient air pollution and pregnancy-induced hypertensive disorders including gestational hypertension and preeclampsia. We searched electronic databases for English language studies reporting associations between ambient air pollution and pregnancy-induced hypertensive disorders published between December 2009 and December 2013. Combined risk estimates were calculated using random-effect models for each exposure that had been examined in ≥4 studies. Heterogeneity and publication bias were evaluated. A total of 17 articles evaluating the impact of nitrogen oxides (NO2, NOX), particulate matter (PM10, PM2.5), carbon monoxide (CO), ozone (O3), proximity to major roads, and traffic density met our inclusion criteria. Most studies reported that air pollution increased risk for pregnancy-induced hypertensive disorders. There was significant heterogeneity in meta-analysis, which included 16 studies reporting on gestational hypertension and preeclampsia as separate or combined outcomes; there was less heterogeneity in findings of the 10 studies reporting solely on preeclampsia. Meta-analyses showed increased risks of hypertensive disorders in pregnancy for all pollutants except CO. Random-effect meta-analysis combined odds ratio associated with a 5-μg/m3 increase in PM2.5 was 1.57 (95% confidence interval, 1.26-1.96) for combined pregnancy-induced hypertensive disorders and 1.31 (95%confidence interval, 1.14-1.50) for preeclampsia [corrected]. Our results suggest that exposure to air pollution increases the risk of pregnancy-induced hypertensive disorders.

KEYWORDS:

air pollution; hypertension, pregnancy-induced; pre-eclampsia; pregnancy

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center