The direct synthesis of N-alkylated amides via a tandem hydration/N-alkylation reaction from nitriles, aldoximes and alcohols

Nana Wang; Xiaoyuan Zou; Juan Ma; Feng Li

doi:10.1039/c4cc02742f

The direct synthesis of N-alkylated amides via a tandem hydration/N-alkylation reaction from nitriles, aldoximes and alcohols

Chem Commun (Camb). 2014 Aug 7;50(61):8303-5. doi: 10.1039/c4cc02742f.

Authors

Nana Wang¹, Xiaoyuan Zou, Juan Ma, Feng Li

Affiliation

¹ Key Laboratory for Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing 210094, P. R. China. fengli@njust.edu.cn.

PMID: 24935726
DOI: 10.1039/c4cc02742f

Abstract

A novel strategy for the direct synthesis of N-alkylated amides from nitriles, aldoximes and alcohols was proposed and accomplished in the presence of a Cp*Ir complex.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohols / chemistry*
Alkylation
Amides / chemical synthesis
Amides / chemistry*
Catalysis
Coordination Complexes / chemistry
Iridium / chemistry
Nitriles / chemistry*
Oximes / chemistry*

Substances

Alcohols
Amides
Coordination Complexes
Nitriles
Oximes
Iridium