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Immunogenetics. 2014 Aug;66(7-8):507-11. doi: 10.1007/s00251-014-0785-2. Epub 2014 Jun 17.

Characterization of a polymorphic IGLV gene in pigs (Sus scrofa).

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1
Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN, 55108, USA, john.schwartz@pirbright.ac.uk.

Abstract

Swine, unlike other artiodactyls, but similar to humans, utilize both lambda and kappa light chain isotypes almost equally in the generation of their antibody repertoire. The porcine antibody light chain loci have previously been characterized in a single Duroc sow in which was seen extensive allelic variation between light chain genes on homologous chromosomes. However, the extent of variation between individuals is completely unknown. Using deep sequencing of cDNA-derived amplicons from five pigs, we report the identification and characterization of an IGLV gene that is functional and highly expressed in some animals, yet completely absent in others. Our findings provide a possible rationale for the known individual-to-individual variation in antibody responses to vaccination, infectious challenge, and subsequent disease outcome.

PMID:
24934119
PMCID:
PMC4119607
DOI:
10.1007/s00251-014-0785-2
[Indexed for MEDLINE]
Free PMC Article
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