Format

Send to

Choose Destination
Stem Cell Res. 2014 Nov;13(3 Pt B):683-92. doi: 10.1016/j.scr.2014.04.007. Epub 2014 Apr 29.

The epicardium signals the way towards heart regeneration.

Author information

1
Department of Physiology Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford OX1 3PT, UK. Electronic address: megan.masters@dpag.ox.ac.uk.
2
Department of Physiology Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford OX1 3PT, UK. Electronic address: paul.riley@dpag.ox.ac.uk.

Abstract

From historical studies of developing chick hearts to recent advances in regenerative injury models, the epicardium has arisen as a key player in heart genesis and repair. The epicardium provides paracrine signals to nurture growth of the developing heart from mid-gestation, and epicardium-derived cells act as progenitors of numerous cardiac cell types. Interference with either process is terminal for heart development and embryogenesis. In adulthood, the dormant epicardium reinstates an embryonic gene programme in response to injury. Furthermore, injury-induced epicardial signalling is essential for heart regeneration in zebrafish. Given these critical roles in development, injury response and heart regeneration, the application of epicardial signals following adult heart injury could offer therapeutic strategies for the treatment of ischaemic heart disease and heart failure.

PMID:
24933704
PMCID:
PMC4241487
DOI:
10.1016/j.scr.2014.04.007
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center