Format

Send to

Choose Destination
Can J Physiol Pharmacol. 2014 Aug;92(8):631-9. doi: 10.1139/cjpp-2014-0006. Epub 2014 Apr 29.

Passion fruit peel extract attenuates bleomycin-induced pulmonary fibrosis in mice.

Author information

1
a SugenLife Sciences Pvt. Ltd., Tirupati, Andhra Pradesh 517 505, India.

Abstract

Idiopathic pulmonary fibrosis is a progressive fatal lung disease characterized by excessive collagen deposition, with no effective treatments. We investigated the efficacy of natural products with high anti-inflammatory activity, such as passion fruit peel extract (PFPE), in a mouse model of bleomycin-induced pulmonary fibrosis (PF). C57BL/6J mice were subjected to a single intratracheal instillation of bleomycin to induce PF. Daily PFPE treatment significantly reduced loss of body mass and mortality rate in mice compared with those treated with bleomycin. While bleomycin-induced PF resulted in elevated total numbers of inflammatory cells, macrophages, lymphocytes, and neutrophils in bronchoalveolar lavage fluid on both days 7 and 21, PFPE administration significantly attenuated these phenomena compared with bleomycin group. On day 7, the decreased superoxide dismutase and myeloperoxidase activities observed in the bleomycin group were significantly restored with PFPE treatment. On day 21, enhanced hydroxyproline deposition in the bleomycin group was also suppressed by PFPE administration. PFPE treatment significantly attenuated extensive inflammatory cell infiltration and accumulation of collagen in lung tissue sections of bleomycin-induced mice on days 7 and 21, respectively. Our results indicate that administration of PFPE decreased bleomycin-induced PF because of anti-inflammatory and antioxidant activities.

KEYWORDS:

bleomycin; bléomycine; bronchoalveolar lavage fluid; fibrose pulmonaire idiopathique; fruit de la passion; idiopathic pulmonary fibrosis; liquide de lavage broncho-alvéolaire; myeloperoxidase; myéloperoxydase; passion fruit; superoxide dismutase; superoxyde dismutase

PMID:
24933624
DOI:
10.1139/cjpp-2014-0006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center