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J Cardiovasc Med (Hagerstown). 2014 Aug;15(8):642-6. doi: 10.2459/JCM.0000000000000010.

The association between apelin-12 levels and paroxysmal supraventricular tachycardia.

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1
aDepartment of Emergency bDepartment of Cardiology cDepartment of Cardiovascular Surgery, Elazig Education and Research Hospital dDepartment of Biochemistry, Firat University Medical Faculty, Elazig, Turkey.

Abstract

AIMS:

Our aim was to investigate the apelin-12 levels in patients with atrioventricular tachyarrhythmias and compare with those in patients with lone atrial fibrillation.

METHODS:

Forty four patients with supraventricular tachycardia as atrial fibrillation, 44 patients with paroxysmal supraventricular tachycardia (P-SVT) as atrioventricular tachyarrhythmias, including atrioventricular nodal reentrant tachycardia or atrioventricular reentrant tachycardia, and 30 age- and sex-matched healthy individuals were included in the study.

RESULTS:

The apelin-12 levels were significantly lower in both atrial fibrillation and P-SVT groups than control group. In post-hoc analysis, there was no significant difference in apelin-12 levels between atrial fibrillation and P-SVT groups (P = 0.9). Patients in atrial fibrillation group and patients in P-SVT group had significantly lower apelin-12 levels than control group, separately (P < 0.001 and P < 0.001, respectively). The sensitivity and specificity values of the apelin-12 levels for predicting SVT, including both atrial fibrillation and atrioventricular reentrant tachycardia or atrioventricular nodal reentrant tachycardia were 64.77 and 90%, respectively (cut-off value was 0.87). The area under the receiver operator characteristic curve was 0.834 for the apelin-12 levels (P = 0.0001).

CONCLUSION:

Apelin-12 levels are lower in patients with atrial fibrillation and P-SVT than control groups. Lower apelin levels in patients with atrial fibrillation and P-SVT would be expected to result in a decrease in the conduction velocity.

PMID:
24933193
DOI:
10.2459/JCM.0000000000000010
[Indexed for MEDLINE]
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