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J Clin Res Pediatr Endocrinol. 2014;6(2):105-10. doi: 10.4274/Jcrpe.1287.

Epidemiology of congenital hypothyroidism in Markazi Province, Iran.

Author information

1
abriz University of Medical Sciences, National Public Health Management Center, Department of Community Medicine, Tabriz, Iran. E-ma-il: zenalali@gmail.com.

Abstract

OBJECTIVE:

The aim of this study was to investigate the epidemiology of congenital hypothyroidism (CH) among newborns in Markazi Province, Iran.

METHODS:

This cross-sectional study was conducted from 2006 to 2012. Blood samples were taken between 3 to 5 days after birth from the heel. Thyroid stimulating hormone (TSH) was tested using the enzyme-linked immunosorbent assay method and was employed as the screening test. Newborns with abnormal screening results (TSH >5 mIU/L) were re-examined. The data were analyzed using SPSS.

RESULTS:

A total of 127 112 infants were screened. Of these, 51.2% were male and 48.8% were female. The coverage rate of the screening program was 100%. Of 6102 recalled subjects (re-call rate 4.8%), 414 cases with CH were detected, yielding a CH prevalence of 1:307 (female:male ratio 1:0.95). The prevalence of permanent and transient CH was 1:581 and 1:628, respectively.

CONCLUSION:

This study reveals that the prevalence of CH is higher compared to worldwide levels. Comprehensive and complementary studies for recognizing related risk factors should be a priority for health system research in this province.

PMID:
24932604
PMCID:
PMC4141571
DOI:
10.4274/Jcrpe.1287
[Indexed for MEDLINE]
Free PMC Article

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