Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2014 Jun 16;9(6):e99040. doi: 10.1371/journal.pone.0099040. eCollection 2014.

Stochasticity in Ca2+ increase in spines enables robust and sensitive information coding.

Author information

1
Undergraduate Department of Bioinformatics and Systems Biology, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
2
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
3
Undergraduate Department of Bioinformatics and Systems Biology, University of Tokyo, Bunkyo-ku, Tokyo, Japan; Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Abstract

A dendritic spine is a very small structure (∼0.1 µm3) of a neuron that processes input timing information. Why are spines so small? Here, we provide functional reasons; the size of spines is optimal for information coding. Spines code input timing information by the probability of Ca2+ increases, which makes robust and sensitive information coding possible. We created a stochastic simulation model of input timing-dependent Ca2+ increases in a cerebellar Purkinje cell's spine. Spines used probability coding of Ca2+ increases rather than amplitude coding for input timing detection via stochastic facilitation by utilizing the small number of molecules in a spine volume, where information per volume appeared optimal. Probability coding of Ca2+ increases in a spine volume was more robust against input fluctuation and more sensitive to input numbers than amplitude coding of Ca2+ increases in a cell volume. Thus, stochasticity is a strategy by which neurons robustly and sensitively code information.

PMID:
24932482
PMCID:
PMC4059641
DOI:
10.1371/journal.pone.0099040
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center