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Oncol Lett. 2014 Jun;7(6):2003-2006. Epub 2014 Mar 31.

Benefits of skin biopsy of senile hemangioma in intravascular large B-cell lymphoma: A case report and review of the literature.

Author information

1
Division of Surgical Pathology, Toyooka Hospital, Toyooka City, Hyogo 668-8501, Japan ; Department of Stem Cell Disorders, Kansai Medical University, Hirakata City, Osaka 573-1010, Japan.
2
Department of Internal General Medicine, Toyooka Hospital, Toyooka City, Hyogo 668-8501, Japan.
3
Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, Kobe City, Hyogo 650-0017, Japan.
4
Department of Internal Medicine, Public Muraoka Hospital, Kami-Cho, Hyogo 667-1311, Japan.
5
Department of Dermatology, Toyooka Hospital, Toyooka City, Hyogo 668-8501, Japan.
6
Department of Clinical Laboratory, Toyooka Hospital, Toyooka City, Hyogo 668-8501, Japan.
7
Department of Stem Cell Disorders, Kansai Medical University, Hirakata City, Osaka 573-1010, Japan.

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of B-cell lymphoma characterized by selective growth of clonal B-cells in the lumen of the small vessels of various organs including the liver, spleen, lungs, skin, brain, and kidney. An 86-year-old male presented with weight loss, fever and night sweats (known as B symptoms). Blood examination revealed pancytopenia, high lactate dehydrogenase and high soluble interleukin-2 receptor, suggesting hematopoietic malignancy. However, there were no abnormal hematopoietic cells in the peripheral blood. No lymph node swelling was identified on examination by whole-body computed tomography scan. Therefore, IVLBCL was suspected, and random skin biopsies and a skin biopsy from a senile hemangioma were carried out. A small number of large atypical lymphoid cells resided in the small blood vessels in the deep dermis and subcutaneous tissue of the random skin biopsies, and numerous atypical lymphoid cells were identified in the small vessels of the senile hemangioma. These results suggest the usefulness of skin biopsy from senile hemangiomas in the diagnosis of IVLBCL.

KEYWORDS:

CD20; intravascular large B-cell lymphoma; senile hemangioma; skin biopsy

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