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Brain Res. 2014 Jul 29;1574:60-9. doi: 10.1016/j.brainres.2014.06.008. Epub 2014 Jun 12.

GILZ: Glitzing up our understanding of the glucocorticoid receptor in psychopathology.

Author information

1
Central Medical School, Monash University, Wellington Rd, Clayton, VIC, Australia. Electronic address: angeline.thiagarajah@gmail.com.
2
Central Medical School, Monash University, Wellington Rd, Clayton, VIC, Australia.
3
Delmont Private Hospital, 298 Warrigal Rd, Glen Iris, VIC, Australia.
4
Department of Medicine, Monash University, Wellington Rd, Clayton, VIC, Australia.
5
Department of Psychiatry, Monash University, Wellington Rd, Clayton, VIC, Australia.

Abstract

Dysfunction of the hypothalamic-pituitary-adrenal axis, particularly the glucocorticoid receptor, is a commonly implicated link between stress and psychopathology. GR abnormalities are frequently reported in depression, and these anomalies must be resolved before depressive symptoms remit. This biological finding is rendered clinically relevant by the knowledge that only select antidepressants alter GR function. The relationship between GR dysfunction and other diseases associated with psychiatric stress, such as post-traumatic stress disorder (PTSD) and fibromyalgia, is also documented. However, as laboratory constraints limit the utility of GR testing, other measures of GR activity, such as levels of GR-induced genes, may have greater clinical value. In this review, glucocorticoid-induced leucine zipper (GILZ), a product of GR-initiated gene transcription, will be discussed in the context of GR dysfunction in psychopathology.

KEYWORDS:

Depression; Fibromyalgia; GILZ; Glucocorticoid receptor; HPA axis; PTSD

PMID:
24931768
DOI:
10.1016/j.brainres.2014.06.008
[Indexed for MEDLINE]

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