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FEBS Lett. 2014 Aug 1;588(15):2422-7. doi: 10.1016/j.febslet.2014.06.019. Epub 2014 Jun 12.

The architect who never sleeps: tumor-induced plasticity.

Author information

1
Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt am Main, Germany.
2
Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Str. 42-44, 60596 Frankfurt am Main, Germany. Electronic address: greten@gsh.uni-frankfurt.de.

Abstract

Tumor cell plasticity is an event that has been observed in several malignancies. In fact, most of the solid tumors are characterized by cellular heterogeneity and undergo constant changes as the tumor develops. The increased plasticity displayed by these cells allows them to acquire additional properties, enabling epithelial-mesenchymal transitions, dedifferentiation and the acquisition of stem cell-like properties. Here we discuss the particular importance of an inflammatory microenvironment for the bidirectional control of cellular plasticity and the potential for therapeutic intervention.

KEYWORDS:

Cancer; Cell plasticity; Tumor microenvironment

PMID:
24931375
PMCID:
PMC4099523
DOI:
10.1016/j.febslet.2014.06.019
[Indexed for MEDLINE]
Free PMC Article

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