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FEBS Lett. 2014 Aug 25;588(17):3038-46. doi: 10.1016/j.febslet.2014.06.017. Epub 2014 Jun 12.

miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth.

Author information

1
Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.
2
Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China. Electronic address: qyfycss@gmail.com.

Abstract

We found that miR-96 is overexpressed in glioma, and its level inversely correlates with the survival of patients. The reduction in miR-96 abundance suppresses the proliferation and colony formation of glioma cells. The tumorigenicity of U-87 MG cells is reduced by miR-96 silencing. miR-96 contributes to the activation of Wnt/β-catenin pathway in glioma cells. HMG-box transcription factor 1 (HBP-1), a Wnt/β-catenin pathway inhibitor, is suppressed by miR-96. The reactivation of Wnt/β-catenin signaling causes an increase in the proliferation of glioma cells, and a decrease in miR-96 expression. On the other hand, HBP1 silencing promotes miR-96 expression. Collectively, miR-96 contributes to the progression of glioma by enhancing the activation of the Wnt/β-catenin pathway, and the miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes the proliferation of glioma cells.

KEYWORDS:

Glioma; HMG-box transcription factor 1; Proliferation; Wnt/β-catenin; miR-96

PMID:
24931370
DOI:
10.1016/j.febslet.2014.06.017
[Indexed for MEDLINE]
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