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Dev Med Child Neurol. 2014 Nov;56(11):1072-7. doi: 10.1111/dmcn.12513. Epub 2014 Jun 14.

Neurophysiological abnormalities in the sensorimotor cortices during the motor planning and movement execution stages of children with cerebral palsy.

Author information

1
Department of Physical Therapy, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA; Center for Magnetoencephalography, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.

Abstract

AIM:

This investigation used magnetoencephalography (MEG) to examine the neural oscillatory responses of the sensorimotor cortices during the motor planning and movement execution stages of children with typical development and children with cerebral palsy (CP).

METHOD:

The study involved 13 children with CP (nine males, four females; mean [SD] age 14y 3mo [9mo], range 10-18y; height 1.61m [0.08m]; weight 52.65kg [13kg]), and 13 age- and sex-matched typically developing children (height 1.64m [0.06m]; weight 56.88kg [10kg]). The experiment required the children to extend their knee joint as whole-head MEG recordings were acquired. Beamformer imaging methods were employed to quantify the source activity of the beta-frequency (14-28Hz) event-related desynchronization (ERD) that occurs during the motor planning period, and the gamma-frequency (~50Hz) event-related synchronization (ERS) that occurs at the motor execution stage.

RESULTS:

The children with CP had a stronger mean beta ERD during the motor planning phase and reduced mean gamma ERS at the onset of movement.

INTERPRETATION:

The uncharacteristic beta ERD in the children with CP suggests that they may have greater difficulty planning knee joint movements. We suggest that these aberrant beta ERD oscillations may have a cascading effect on the gamma ERS, which ultimately affects the execution of the motor command.

PMID:
24931008
PMCID:
PMC4194152
DOI:
10.1111/dmcn.12513
[Indexed for MEDLINE]
Free PMC Article
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