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J Am Acad Dermatol. 2014 Oct;71(4):764-71. doi: 10.1016/j.jaad.2014.05.047. Epub 2014 Jun 12.

Photodynamic therapy using chlorophyll-a in the treatment of acne vulgaris: a randomized, single-blind, split-face study.

Author information

  • 1Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.
  • 2Department of Dermatology, Seoul National University College of Medicine, Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea.
  • 3Seoul 365mc Obesity Hospital, Seoul, Korea. Electronic address: kwinho@paran.com.

Abstract

BACKGROUND:

Chlorophyll-a is a novel photosensitizer recently tested for the treatment of acne vulgaris.

OBJECTIVE:

We sought to evaluate the clinical efficacy and safety of chlorophyll-a photodynamic therapy used for acne treatment.

METHODS:

Subjects with acne on both sides of the face were included. Eight treatment sessions were performed over a 4-week duration. Half of the face was irradiated using a blue and red light-emitting diode after topical application of chlorophyll-lipoid complex. The other half underwent only light-emitting diode phototherapy. The lesion counts and acne severity were assessed by a blinded examiner. Sebum secretion, safety, and histologic changes were also evaluated.

RESULTS:

In total, 24 subjects completed the study. Facial acne improved on both treated sides. On the chlorophyll-a photodynamic therapy-treated side, there were significant reductions in acne lesion counts, acne severity grades, and sebum levels compared with the side treated with light-emitting diode phototherapy alone. The side effects were tolerable in all the cases.

LIMITATIONS:

All the subjects were of Asian descent with darker skin types, which may limit the generalizability of the study. A chlorophyll-a arm alone is absent, as is a no-treatment arm.

CONCLUSIONS:

We suggest that chlorophyll-a photodynamic therapy for the treatment of acne vulgaris can be effective and safe with minimal side effects.

KEYWORDS:

acne vulgaris; chlorophyll-a; light-emitting diode; photodynamic therapy; photosensitizer; treatment

PMID:
24930587
DOI:
10.1016/j.jaad.2014.05.047
[PubMed - indexed for MEDLINE]
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