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Pediatr Transplant. 2014 Aug;18(5):E169-73. doi: 10.1111/petr.12294. Epub 2014 Jun 14.

Successful lung transplant in a child with cystic fibrosis and persistent Blastobotrys rhaffinosifermentans infection.

Author information

1
University of Alberta, Edmonton, AB, Canada.

Abstract

Fungal respiratory infections in patients with CF are a significant concern both pre- and post-lung transplantation (LTx). Fungal infection is associated with increased mortality post-LTx, and in the past decade, the prevalence of fungal colonization in Canadian pediatric patients with CF has increased. The emergence of novel fungal pathogens is particularly challenging to the transplant community, as little is known regarding their virulence and optimal management. We present a case of a successful double-lung transplant in a pediatric patient with CF who was infected pretransplantation with a novel yeast, Blastobotrys rhaffinosifermentans. This patient was treated successfully with aggressive antifungal therapy post-transplantation, followed by extended fungal prophylaxis. The significance of fungal colonization and infection in children with CF pre- and post-LTx is reviewed.

KEYWORDS:

fungal infection; fungal infections - cystic fibrosis; lung transplantation; pediatric lung transplantation; pediatric transplantation

PMID:
24930454
DOI:
10.1111/petr.12294
[Indexed for MEDLINE]

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