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Environ Toxicol Pharmacol. 2014 Jul;38(1):131-40. doi: 10.1016/j.etap.2014.05.007. Epub 2014 May 27.

An acute exposure to glyphosate-based herbicide alters aromatase levels in testis and sperm nuclear quality.

Author information

1
University of Caen, Institute of Biology, Network on Risks MRSH-CNRS, Esplanade de la Paix, 14032 Caen Cedex, France; CRIIGEN, 40 rue de Monceau, 75008 Paris, France. Electronic address: estelle.cassault-meyer@unicaen.fr.
2
University of Caen, Institute of Biology, Network on Risks MRSH-CNRS, Esplanade de la Paix, 14032 Caen Cedex, France; CRIIGEN, 40 rue de Monceau, 75008 Paris, France. Electronic address: steeve-gress@hotmail.fr.
3
University of Caen, Institute of Biology, Network on Risks MRSH-CNRS, Esplanade de la Paix, 14032 Caen Cedex, France; CRIIGEN, 40 rue de Monceau, 75008 Paris, France. Electronic address: criigen@unicaen.fr.
4
University of Caen, Institute of Biology, Network on Risks MRSH-CNRS, Esplanade de la Paix, 14032 Caen Cedex, France. Electronic address: idenis1@orange.fr.

Abstract

Roundup is the major pesticide used in agriculture worldwide; it is a glyphosate-based herbicide. Its molecular effects are studied following an acute exposure (0.5%) of fifteen 60-day-old male rats during an 8-day period. Endocrine (aromatase, estrogen and androgen receptors, Gper1 in testicular and sperm mRNAs) and testicular functions (organ weights, sperm parameters and expression of the blood-testis barrier markers) were monitored at days 68, 87, and 122 after treatment, spermiogenesis and spermatogenesis. The major disruption is an increase of aromatase mRNA levels at least by 50% in treated rats at all times, as well as the aromatase protein. We have also shown a similar increase of Gper1 expression at day 122 and a light modification of BTB markers. A rise of abnormal sperm morphology and a decrease of the expression of protamine 1 and histone 1 testicular in epididymal sperm are observed despite a normal sperm concentration and motility.

KEYWORDS:

Aromatase (P450 arom); Glyphosate; Nuclear quality; Roundup; Spermatozoa; Testis

PMID:
24930125
DOI:
10.1016/j.etap.2014.05.007
[Indexed for MEDLINE]

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