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Circulation. 2014 Jul 29;130(5):390-8. doi: 10.1161/CIRCULATIONAHA.113.007627. Epub 2014 Jun 13.

Patterns of alcohol consumption and myocardial infarction risk: observations from 52 countries in the INTERHEART case-control study.

Collaborators (427)

Yusuf S, Ounpuu S, Montague P, Keys J, Rangarajan S, Hawken S, Negassa A, Wright C, Mayhew R, Westfall L, Mackie P, Cuvay C, Cunningham D, Picken K, Gerstein H, McQueen M, Hall K, Keys J, Diaz R, Paolasso E, Ciruzzi M, Nordaby R, Sosa CH, Luciardi HL, Marzetti EM, Piasentin JA, Amuchastegui M, Cuneo C, Zapata G, Bono JO, Marxetti EM, Caccavo A, Guerrero RA, Nordaby R, Dizeo C, Hunt D, Varigos J, Sallaberger M, Aroney G, Hicks P, Campbell D, Amerena J, Walsh W, Nelson G, Careless D, Durech J, Gunawardane K, Thomson A, Owensby D, Buncle A, Watson B, Ikram H, Audeau M, Hills M, Rosen D, Rankin J, Tunesi A, Sampson J, Roberts K, Hamer A, Roberts L, Singh B, Singh C, Hendriks R, Tulloch G, Hill A, Rees D, Hall C, Halim MA, Amin MI, Haque S, Furuque GM, Hossain M, Agboton H, Onen C, Avezum A, Piegas L, Reis G, Esteves JP, Bodanese LC, Junior AR, Neto JA, Ramos RF, Silva ES, Labrunie A, Carvalho AC, Filho IP, Albuquerque DC, Abrantes JA, Gebara OC, Leaes PE, Xavier SS, Marino RL, Dutra O, Muna W, Blackett KN, Teo K, Yusuf S, Ounpuu S, Chan YK, Joyner C, Kitching AD, Morris A, Panju A, Lee H, Bata I, May B, Hiscock JG, Greenwood PV, Tymchak W, Natarajan M, Lanas F, Standen D, Lanas A, Santibanez C, Soto P, Potthoff S, Soto R, Mercadal E, Liu LS, Jiang LX, Chen Q, Sun N, Wang J, Zhang L, Li X, Chen H, Li Z, Shi Y, Meng J, Wang D, Liu Z, Yan J, Zhang W, Wan Z, Xu Y, Li X, Wang L, Fu Q, Zhu K, Wang Y, Wang X, Wang F, Liu R, Zhao R, Sun K, Yue S, Zhang Y, Zhao X, Zhao L, Zhou C, Meng X, Liu A, Li X, Wu R, Xiao R, Zhang X, Wan G, Chen X, Ge Z, Zhou T, Li Y, Zhou X, Zhang F, Bautista LE, Casas JP, Morillo CA, Ardilla CA, Arenas IA, Lindarte M, Aristizabal D, Rumboldt Z, Rumboldt M, Carevic V, Widimsky P, Branny M, Gregor P, Khedr MS, Abdel-Aziz MG, Abdel-Kader S, Abdel-Moneim MA, El-Demerdash F, El-Saiid A, Gharib S, Hassanin M, Abdel-Hamid Maklady F, Sadek I, Rupprecht HJ, Wittlinger T, Schuster P, Schmidt A, Ochs HR, Karatzas N, Pipilis A, Symeonides D, Karidis K, Tsaknakis TH, Kyfnidis K, Luna M, Arroyo AM, Sotomora G, Rodas MA, Velasquez L, Ovando A, Sanderson J, Ma WY, Chan S, Keltai M, Szaboki F, Karpati P, Toth K, Timar S, Kalo E, Janosi A, Rusznak M, Lehoczky D, Tarjan J, Kiss E, Sitkei E, Valyi P, Edes I, Pais P, Reddy KS, Joshi PP, Prabhakaran D, Xavier D, Roy A, Ramakrishnan L, Hasani MR, Mirkhani SH, Halon D, Lewis B, Franzosi MG, Tognoni G, Gardinale E, Villella M, Mennuni M, Saiu F, Pettinati G, Ciricugno S, Antonaci S, Carrieri L, Balli E, Bicego D, DelleDonne MG, Ottaviano A, Moretti L, Melloni C, Melandri G, Carbonieri E, Vetrano A, Hori M, Sato H, Fujii K, Ogola EN, Wangai P, Zubaid M, Rashed W, Lang CC, Ahmad WA, Kadirvelu A, Zambahari R, Ramos-Corrales MA, Damasceno A, Pandey MR, Baniya G, Sayami A, Kiratee M, Rawat B, Pandey M, Gurung J, Peters R, Basart DC, Bronzwaer PN, Heijmeriks JA, Michels HR, Pop GM, Akinroye KK, Kazmi K, Memon NA, Memon SK, Nishtar S, Badar A, Mattu MA, Yakub M, Soomra K, Khatri J, Faruqui AM, Rasool SI, Samad A, Dans AL, Punzalan FQ, Villarruz MV, Mendoza BT, Recto CS 3rd, Tamesis BR, Mendoza V, Torres DJ, Morales DD, Ongtengco I, Budaj A, Ceremuzynski L, Stec S, Gorny J, Prochniewska K, Urbanek TK, Wojewoda P, Pawlowski M, Religa K, Klabisz R, Latocha H, Szpajer M, Cymerman K, Laniec M, Danielewicz H, Ogorek M, Kopcik D, Baranowska A, Kozlowski A, Blachowicz M, Jedrzejowski A, Waszyrowski T, Zielinski Z, Janik K, Tomzynski M, Mytnik M, Maziarz A, Rembelska G, Piepiorka M, Debkowska K, Krynski T, Szczeklik BS, Krasowski W, Rozwodowska M, Miekus P, Surwilo J, Malinowski S, Hybel J, Michalak M, Achremczyk P, Majchrzak J, Korombel WS, Dobrowolski M, Gessek J, Morais J, Gehani AA, Hajar HA, Almowla MM, Omer AA, Volkova EG, Levashov SU, Filatova OM, Evchenko UI, Malkiman GS, Karaulovskaya NN, Panovsky J, Johan BA, Cheng A, Ng KS, Lim YL, Neoh KH, Tan KS, Lum LN, Cheah Y, Commerford P, Steyn K, Brown B, Martiz F, Raubenheimer P, Aboo A, Marx JD, Batiste E, Sliwa K, Sareli P, Zambiakides C, Valentin V, Ferriz J, Rovira A, Rodriguez-Llorian A, Cereijo E, Monzo T, Alonso N, Gomez-Martinez E, Lopez A, Mendis S, Jayalath T, Hinai AT, Hassan MO, Rosengren A, Sitthi-Amorn C, Chaithiraphan S, Bhuripanyo K, Srimahachota S, Anukulwutipong M, Loothavorn P, Sritara P, Tanomsup S, Tantitham J, Tatsanavivat P, Yipinsoi T, Jintapakorn W, Puavilai W, Koanantakul B, Kasemsuwan P, Supanantareauk C, Peamsomboon C, Saejueng B, Jeamsomboon K, Sukontasup A, Almahmeed W, Abdelwareth LO, Bokhari A, Rao NS, Bakir S, Yusufali AM, Hatou E, Zaidi Q, Fox K, Flather M, Probstfield J, Freeman R, Mathew J, Schweiger M, Johnson W, Ofili E, Chifamba J, Hakim AJ.

Author information

1
From the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (D.P.L., A.S., K.K.T., S.R., S.S.A., S.Y.); London School of Hygiene and Tropical Medicine, London, UK (M.M.); St. John's Medical College, Bangalore, India (P.P.); and Fu Wai Hospital, Beijing, China (L.L.). leongd@phri.ca.
2
From the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada (D.P.L., A.S., K.K.T., S.R., S.S.A., S.Y.); London School of Hygiene and Tropical Medicine, London, UK (M.M.); St. John's Medical College, Bangalore, India (P.P.); and Fu Wai Hospital, Beijing, China (L.L.).

Abstract

BACKGROUND:

Although moderate alcohol use is associated with protection against myocardial infarction (MI), it is not known whether this effect is generalizable to populations worldwide. It is also uncertain whether differences in the pattern of alcohol use (and in particular heavy episodic consumption) between different regions negate any beneficial effect.

METHODS AND RESULTS:

We included 12 195 cases of first MI and 15 583 age- and sex-matched controls from 52 countries. Current alcohol use was associated with a reduced risk of MI (compared with nonusers: adjusted odds ratio, 0.87; 95% confidence interval, 0.80-0.94; P=0.001); however, the strength of this association was not uniform across different regions (region-alcohol interaction P<0.001). Heavy episodic drinking (≥6 drinks) within the preceding 24 hours was associated with an increased risk of MI (odds ratio, 1.4; 95% confidence interval, 1.1-1.9; P=0.01). This risk was particularly elevated in older individuals (for age >65 years: odds ratio, 5.3; 95% confidence interval, 1.6-18; P=0.008).

CONCLUSIONS:

In most participants, low levels of alcohol use are associated with a moderate reduction in the risk of MI; however, the strength of this association may not be uniform across different countries. An episode of heavy drinking is associated with an increased risk of acute MI in the subsequent 24 hours, particularly in older individuals.

KEYWORDS:

alcohol drinking; epidemiology; myocardial infarction; risk factors

[Indexed for MEDLINE]

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