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Methods Mol Biol. 2014;1164:211-8. doi: 10.1007/978-1-4939-0805-9_17.

Repositioning monocyte TFRN into fibroblasts.

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  • 1Division of Genomics Technologies, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.

Abstract

Repositioning of cell-specific Transcription Factor Regulatory Networks (TFRNs) into another cell type is a pragmatic approach to elicit desired functions in impaired cells and also to investigate transcription regulations underlying cellular functions. However, a systematic method to identify a set of transcription factors (TFs) which can efficiently promote TFRN in a foreign cell type is lacking. Here, we demonstrate a perturbation-matrix method for the identification and repositioning of monocyte TFRNs in dermal fibroblasts.

PMID:
24927846
DOI:
10.1007/978-1-4939-0805-9_17
[PubMed - indexed for MEDLINE]
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