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PLoS One. 2014 Jun 13;9(6):e99567. doi: 10.1371/journal.pone.0099567. eCollection 2014.

Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer.

Author information

1
INSERM, UMR1101, LaTIM, CHRU Morvan, Brest, France.
2
Institute of Nuclear Medicine, UCL, Euston Road, London, United Kingdom.
3
Division of Imaging Sciences and Biomedical Engineering, Kings College London, St Thomas Hospital, London, United Kingdom.
4
Epidemiology & Biostatistics, CIC Inserm 1402, CHU Milétrie, Poitiers, France.
5
Department of Nuclear Medicine, CHU Miletrie, Poitiers, France.

Abstract

METHODS:

Thirty patients with proven colorectal cancer prospectively underwent integrated 18F-FDG PET/DCE-CT to assess the metabolic-flow phenotype. Both CT blood flow parametric maps and PET images were analyzed. Correlations between PET heterogeneity and perfusion CT were assessed by Spearman's rank correlation analysis.

RESULTS:

Blood flow visualization provided by DCE-CT images was significantly correlated with 18F-FDG PET metabolically active tumor volume as well as with uptake heterogeneity for patients with stage III/IV tumors (|ρ|:0.66 to 0.78; p-value<0.02).

CONCLUSION:

The positive correlation found with tumor blood flow indicates that intra-tumor heterogeneity of 18F-FDG PET accumulation reflects to some extent tracer distribution and consequently indicates that 18F-FDG PET intra-tumor heterogeneity may be associated with physiological processes such as tumor vascularization.

PMID:
24926986
PMCID:
PMC4057188
DOI:
10.1371/journal.pone.0099567
[Indexed for MEDLINE]
Free PMC Article

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