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Cell Rep. 2014 Jun 12;7(5):1341-2. doi: 10.1016/j.celrep.2014.05.052.

AKAP5 keeps L-type channels and NFAT on their toes.

Author information

  • 1Department of Pharmacology, University of California, Davis, CA 95615, USA. Electronic address: mfnavedo@ucdavis.edu.
  • 2Department of Pharmacology, University of California, Davis, CA 95615, USA. Electronic address: jwhell@ucdavis.edu.

Abstract

In this issue of Cell Reports, Murphy et al. and Dittmer et al. present exciting new insight into the regulation of Ca2+ influx via the L-type Ca2+ channel Cav1.2 and how increased Ca2+ influx translates into localized activation of the nuclear transcription factor NFAT upon depolarization in neurons.

PMID:
24926793
DOI:
10.1016/j.celrep.2014.05.052
[PubMed - indexed for MEDLINE]
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