Sirolimus-related systemic thrombotic microangiopathy after renal transplantation

Simone Negrini; Antoine Durrbach; Laurent Becquemont

doi:10.2515/therapie/2014020

Sirolimus-related systemic thrombotic microangiopathy after renal transplantation

Therapie. 2014 Mar-Apr;69(2):175-7. doi: 10.2515/therapie/2014020. Epub 2014 Jun 12.

Authors

Simone Negrini¹, Antoine Durrbach², Laurent Becquemont¹

Affiliations

¹ Centre de Recherche clinique Paris-Sud, Le Kremlin-Bicêtre, France.
² Service de Néphrologie, Dialyse et Transplantation, IFRNT, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

PMID: 24926637
DOI: 10.2515/therapie/2014020

Abstract

We describe the case of a renal transplant patient who developed de novo biopsy-proven thrombotic microangiopathy (TMA) and deep venous thrombosis after treatment with sirolimus (SRL). We discuss the clinical course, diagnosis and therapeutics of this patient in the context of the literature.

Publication types

Case Reports
Letter

MeSH terms

Aged
Humans
Immunosuppressive Agents / administration & dosage
Immunosuppressive Agents / adverse effects*
Kidney / blood supply
Kidney / pathology
Kidney Transplantation* / adverse effects
Male
Sirolimus / administration & dosage
Sirolimus / adverse effects*
Thrombotic Microangiopathies / chemically induced*
Thrombotic Microangiopathies / diagnosis
Transplantation Conditioning / adverse effects
Venous Thrombosis / chemically induced
Venous Thrombosis / diagnosis

Substances

Immunosuppressive Agents
Sirolimus