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Dement Geriatr Cogn Dis Extra. 2014 Apr 25;4(1):103-12. doi: 10.1159/000360280. eCollection 2014 Jan.

Decreased motor function is associated with poorer cognitive function in elderly with type 2 diabetes.

Author information

1
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA.
2
The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, USA.
3
Maccabi Healthcare Services, University of Tel Aviv, Tel-Aviv, Israel ; Sackler Faculty of Medicine, University of Tel Aviv, Tel-Aviv, Israel.
4
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA ; James J. Peters Veterans Affairs Medical Center, Bronx, N.Y., USA.
5
Maccabi Healthcare Services, University of Tel Aviv, Tel-Aviv, Israel.
6
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA ; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, USA.

Abstract

BACKGROUND/AIMS:

Impaired motor function has been associated with cognitive impairment and dementia, but this relationship is poorly understood in elderly with type 2 diabetes (T2D). We thus investigated it in a large sample (n = 726) of cognitively normal elderly with T2D.

METHODS:

In this cross-sectional study, hierarchical linear regressions assessed correlations of 3 motor measures (timed walk, grip strength, and self-reported motor difficulties) with episodic memory, attention/working memory, semantic categorization, executive function, and overall cognition controlling for demographics.

RESULTS:

Longer timed walk and weaker grip strength were associated with poorer performance in all cognitive domains except episodic memory.

CONCLUSIONS:

Associations of motor and cognitive functions in T2D and non-T2D samples are consistent. A lack of association of motor function with episodic memory may suggest non-Alzheimer's disease-related underlying mechanisms.

KEYWORDS:

Cognition; Dementia; Elderly; Memory; Motor function; Type 2 diabetes

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