Format

Send to

Choose Destination
Science. 2014 Jun 13;344(6189):1280-5. doi: 10.1126/science.1251688. Epub 2014 Jun 12.

Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits.

Author information

1
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. cdbustam@stanford.edu morenoe@stanford.edu esteban.burchard@ucsf.edu.
2
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. cdbustam@stanford.edu morenoe@stanford.edu esteban.burchard@ucsf.edu.
3
Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
4
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
5
Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Department of Genetics, Evolution and Environment, University College London, London, UK.
6
Department of Medicine, University of California, San Francisco, CA, USA.
7
Instituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, Mexico.
8
Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
9
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
10
Department of Medicine, University of California, San Francisco, CA, USA. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.
11
The Brooklyn Hospital Center, Brooklyn, NY, USA.
12
Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico.
13
Veterans Caribbean Health Care System, San Juan, Puerto Rico.
14
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
15
International Agency for Research on Cancer, Lyon, France.
16
Hospital Infantil de México Federico Gomez, Mexico City, Mexico.
17
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
18
Department of Genetics, Evolution and Environment, University College London, London, UK.
19
Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico. Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico.
20
Department of Medicine, University of California, San Francisco, CA, USA. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. cdbustam@stanford.edu morenoe@stanford.edu esteban.burchard@ucsf.edu.

Abstract

Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.

PMID:
24926019
PMCID:
PMC4156478
DOI:
10.1126/science.1251688
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Grant support

Publication types

MeSH terms

Grant support

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center