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Science. 2014 Jul 4;345(6192):87-90. doi: 10.1126/science.1253286. Epub 2014 Jun 12.

Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors.

Author information

1
Institut de Biologie de l'École Normale Supérieure, Inserm U1024, and CNRS UMR 8197, 75005 Paris, France.
2
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
3
Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.
4
Institut de Biologie de l'École Normale Supérieure, Inserm U1024, and CNRS UMR 8197, 75005 Paris, France. jfbrunet@biologie.ens.fr.

Abstract

Neural crest cells migrate extensively and give rise to most of the peripheral nervous system, including sympathetic, parasympathetic, enteric, and dorsal root ganglia. We studied how parasympathetic ganglia form close to visceral organs and what their precursors are. We find that many cranial nerve-associated crest cells coexpress the pan-autonomic determinant Paired-like homeodomain 2b (Phox2b) together with markers of Schwann cell precursors. Some give rise to Schwann cells after down-regulation of PHOX2b. Others form parasympathetic ganglia after being guided to the site of ganglion formation by the nerves that carry preganglionic fibers, a parsimonious way of wiring the pathway. Thus, cranial Schwann cell precursors are the source of parasympathetic neurons during normal development.

PMID:
24925912
DOI:
10.1126/science.1253286
[Indexed for MEDLINE]
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