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Science. 2014 Jul 4;345(6192):82-7. doi: 10.1126/science.1253281. Epub 2014 Jun 12.

Neurodevelopment. Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.

Author information

1
Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. A.V. Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia.
2
Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
3
Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
4
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
5
Division of Molecular Neurobiology, Medical Research Council (MRC) National Institute for Medical Research, London, UK.
6
Department of Neuroscience, The Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany.
7
Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. igor.adameyko@ki.se patrik.ernfors@ki.se.
8
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. igor.adameyko@ki.se patrik.ernfors@ki.se.

Abstract

The peripheral autonomic nervous system reaches far throughout the body and includes neurons of diverse functions, such as sympathetic and parasympathetic. We show that the parasympathetic system in mice--including trunk ganglia and the cranial ciliary, pterygopalatine, lingual, submandibular, and otic ganglia--arise from glial cells in nerves, not neural crest cells. The parasympathetic fate is induced in nerve-associated Schwann cell precursors at distal peripheral sites. We used multicolor Cre-reporter lineage tracing to show that most of these neurons arise from bi-potent progenitors that generate both glia and neurons. This nerve origin places cellular elements for generating parasympathetic neurons in diverse tissues and organs, which may enable wiring of the developing parasympathetic nervous system.

PMID:
24925909
DOI:
10.1126/science.1253281
[Indexed for MEDLINE]
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