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Int Immunopharmacol. 2014 Aug;21(2):456-63. doi: 10.1016/j.intimp.2014.05.030. Epub 2014 Jun 9.

Linalool attenuates lung inflammation induced by Pasteurella multocida via activating Nrf-2 signaling pathway.

Author information

1
Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, PR China.
2
Institute of Medicinal Chemistry and Pharmacology, Inner Mongolia University for Nationalities, Tongliao City, Inner Mongolia Autonomous Region 028000, PR China.
3
Département de Médecine Vétérinaire, Institut Supérieur des Sciences et de Médecine Vétérinaire (ISSMV) de Dalaba, Guinée.
4
Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, PR China. Electronic address: fhh70@163.com.

Abstract

Pasteurellosis caused by Pasteurella multocida manifest often as respiratory infection in farmed small ruminants. Although the incidence of pasteurellosis due to P. multocida mainly takes the form of pneumonia, there is limited information on host factors that play a role in disease pathogenesis in the milieu of host-pathogen interactions. Nuclear factor-erythroid 2 related factor 2 (Nrf-2), a critical regulator for various inflammatory and immune responses by controlling oxidative stress, may play an important role in the processes of inflammation induced by P. multocida. In this study, linalool, a natural compound of the essential oils in several aromatic plant species, elevated nuclear Nrf-2 protein translocation in the A549 lung cell line and in vivo. The P. multocida-induced pro-inflammatory cytokines expression was abrogated by Nrf-2 siRNA. Postponed treatment with linalool decreased lung neutrophil accumulation and enhanced clearance of P. multocida. Furthermore, linalool significantly increased the expression of antioxidant enzymes regulated by Nrf-2 and diminished lung tissue levels of several pro-inflammatory cytokines, including tumor necrosis factor α (TNF-α) and interleukin (IL)-6. In addition, animals treated with linalool had a marked improvement in survival. These findings have uncovered that linalool acts as a novel Nrf-2 activator for a novel therapeutic strategy in pathogen-mediated lung inflammation.

KEYWORDS:

Antioxidant; Linalool; Lung inflammation; Nrf-2

PMID:
24925757
DOI:
10.1016/j.intimp.2014.05.030
[Indexed for MEDLINE]

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