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Cancer Res. 2014 Jul 1;74(13):3381-9. doi: 10.1158/0008-5472.CAN-14-0734. Epub 2014 Jun 12.

The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia?

Author information

1
Authors' Affiliations: Departments of Medicine; Surgery;
2
Surgery; Pathology; Oncology;
3
Authors' Affiliations: Departments of Medicine;
4
Pathology; Oncology; Department of Epidemiology, the Bloomberg School of Public Health, Baltimore, Maryland.
5
Oncology; Radiation Oncology; and.
6
Authors' Affiliations: Departments of Medicine; Pathology; Oncology;
7
Radiology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine; and.
8
Surgery;
9
Oncology;
10
Pathology; Oncology;
11
Pathology; Oncology; rhruban@jhmi.edu.

Abstract

Pancreatic cancer is the deadliest of all solid malignancies. Early detection offers the best hope for a cure, but characteristics of this disease, such as the lack of early clinical symptoms, make the early detection difficult. Recent genetic mapping of the molecular evolution of pancreatic cancer suggests that a large window of opportunity exists for the early detection of pancreatic neoplasia, and developments in cancer genetics offer new, potentially highly specific approaches for screening of curable pancreatic neoplasia. We review the challenges of screening for early pancreatic neoplasia, as well as opportunities presented by incorporating molecular genetics into these efforts.

PMID:
24924775
PMCID:
PMC4085574
DOI:
10.1158/0008-5472.CAN-14-0734
[Indexed for MEDLINE]
Free PMC Article

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