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J Invest Dermatol. 2014 Jul;134(7):1789-1791. doi: 10.1038/jid.2014.66.

RNA-seq permits a closer look at normal skin and psoriasis gene networks.

Author information

1
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA; Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway; Faculty of Medicine, K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: dquigley@cc.ucsf.edu.

Abstract

Psoriasis is a chronic inflammatory skin disease driven by aberrant signals from the immune system. In this issue, Li et al. present the first large RNA-seq analysis of gene expression in normal skin and psoriasis lesions, providing a more comprehensive view of mRNA expression than earlier microarray studies. This study's size enables gene co-expression analysis, a method illustrating which pathways are altered by the presence of disease.

PMID:
24924757
PMCID:
PMC4058644
DOI:
10.1038/jid.2014.66
[Indexed for MEDLINE]
Free PMC Article

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