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J Cell Biochem. 2014 Nov;115(11):1996-2003. doi: 10.1002/jcb.24871.

Efficacy of tumor-targeting Salmonella typhimurium A1-R on nude mouse models of metastatic and disseminated human ovarian cancer.

Author information

1
AntiCancer, Inc., San Diego, California; Department of Surgery, University of California San Diego, San Diego, California; Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Abstract

We report here the efficacy of tumor-targeting Salmonella typhimurium A1-R (A1-R) on mouse models of disseminated and metastatic ovarian cancer. The proliferation-inhibitory efficacy of A1-R on human ovarian cancer cell lines (SKOV-3-GFP, OVCAR-3-RFP) was initially demonstrated in vitro. Orthotopic and dissemination mouse models of ovarian cancer were made with the human ovarian cancer cell line SKOV-3-GFP. After tumor implantation, the mice were treated with A1-R (5 × 10(7)  colony-forming units [CFU], i.v.), and there were no severe adverse events observed. In the orthotopic model, tumor volume after treatment was 276 ± 60.8 mm(3), compared to 930 ± 342 mm(3) in the untreated control group (P = 0.022). There was also a significant difference in survival between treated mice and untreated mice in a peritoneal dissemination model (P = 0.005). The results of this report demonstrate that A1-R is effective for highly aggressive human ovarian cancer in metastatic and dissemination mouse models and suggest its clinical potential for this highly treatment-resistant disease.

KEYWORDS:

BACTERIA; GFP; IMAGING; NUDE MICE; OVARIAN CANCER; Salmonella typhimurium; TUMOR-TARGETING

PMID:
24924355
DOI:
10.1002/jcb.24871
[Indexed for MEDLINE]

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