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Wiley Interdiscip Rev RNA. 2014 Sep-Oct;5(5):713-22. doi: 10.1002/wrna.1241. Epub 2014 Jun 12.

Emerging mechanisms of mRNP remodeling regulation.

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1
Department of Biochemistry and Molecular Biology, The University of Texas, Medical School at Houston, Houston, TX, USA.

Abstract

The assembly and remodeling of the components of messenger ribonucleoprotein particles (mRNPs) are important in determining the fate of a messenger RNA (mRNA). A combination of biochemical and cell biology research, recently complemented by genome-wide high-throughput approaches, has led to significant progress on understanding the formation, dynamics, and function of mRNPs. These studies also advanced the challenging process of identifying the evolving constituents of individual mRNPs at various stages during an mRNA's lifetime. While research on mRNP remodeling in general has been gaining momentum, there has been relatively little attention paid to the regulatory aspect of mRNP remodeling. Here, we discuss the results of some new studies and potential mechanisms for regulation of mRNP remodeling.

PMID:
24923990
PMCID:
PMC4323169
DOI:
10.1002/wrna.1241
[Indexed for MEDLINE]
Free PMC Article
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