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Anticancer Res. 2014 Jun;34(6):2735-43.

Decreased VDR expression in cutaneous melanomas as marker of tumor progression: new data and analyses.

Author information

1
Department of Tumor Pathology and Pathomorphology, Oncology Centre, Prof. Franciszek Łukaszczyk Memorial Hospital, The Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland anna.brozyna@cm.umk.pl aslominski@uthsc.edu.
2
Department of Tumor Pathology and Pathomorphology, Oncology Centre, Prof. Franciszek Łukaszczyk Memorial Hospital, The Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
3
Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, U.S.A. Division of Dermatology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, U.S.A. anna.brozyna@cm.umk.pl aslominski@uthsc.edu.

Abstract

BACKGROUND:

Vitamin D3, acting via vitamin D receptor (VDR) affects a wide range of biological activities, including inhibition of proliferation and angiogenesis, with net antitumor effects. VDR expression is disturbed in many tumors, including melanomas.

AIM:

To find correlation between VDR expression in melanomas and prognostic biomarkers.

MATERIALS AND METHODS:

VDR was analyzed immunohistochemically in 69 cutaneous melanomas in relation to prognostic factors.

RESULTS:

Less advanced melanomas showed significantly higher VDR expression than the advanced stages. The presence of other markers such as ulceration and lack or non-brisk tumor infiltrating lymphocytes (TILs) was accompanied by significantly lower VDR expression. VDR expression also affected overall survival (OS) with most noticeable effect in the cases without ulceration.

CONCLUSION:

High VDR expression determines a less malignant phenotype and is related to better prognosis. Loss of VDR expression affects melanoma tumor behavior, allowing for progression of disease. VDR expression can also serve as a prognostic marker in routine histopathology evaluation.

KEYWORDS:

Skin melanoma; tumor progression; vitamin D receptor

PMID:
24922634
PMCID:
PMC4273563
[Indexed for MEDLINE]
Free PMC Article

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