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J Nat Prod. 2014 Jun 27;77(6):1438-44. doi: 10.1021/np500178s. Epub 2014 Jun 12.

Diterpenes from the endangered goldenrod Solidago shortii.

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Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc. , 1912 Innerbelt Business Center Drive, St. Louis, Missouri 63114, United States.


Species extinction is tantamount to loss of chemical diversity, and so it is important to seize all opportunities to study species on the brink of extinction. Such studies are often hampered by the limited material available, but that obstacle is surmountable through collaboration with botanical gardens and advances in instrumentation. The goldenrod Solidago shortii is one example of an endangered species native to the United States. From S. shortii, one known diterpene (1), two new diterpenes (2 and 3), and three new hydrolysis products (4-6) are described. This work was made possible through collaboration with the Missouri Botanical Garden and with the use of highly sensitive microcryoprobe NMR technology for structure elucidation and VCD spectroscopy for the determination of absolute configuration.

[Indexed for MEDLINE]

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