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J Clin Microbiol. 2014 Sep;52(9):3406-10. doi: 10.1128/JCM.01291-14. Epub 2014 Jun 11.

Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility.

Author information

1
Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan Medical Microbiology Laboratory, Funabashi Municipal Medical Center, Funabashi, Chiba, Japan.
2
Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan.
3
Department of Bacteriology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan.
4
Department of Bacteriology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan yarakawa@med.nagoya-u.ac.jp.

Abstract

We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTB(r) PSGBS). The CTB(r) PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-binding protein 2X (PBP 2X) and a T567I substitution in PBP 2B, together with an additional G429S substitution in PBP 2X or a T145A substitution in PBP 1A, although the T145A substitution in the transglycosidase domain of PBP 1A would have no effect on the level of resistance to ceftibuten.

PMID:
24920773
PMCID:
PMC4313170
DOI:
10.1128/JCM.01291-14
[Indexed for MEDLINE]
Free PMC Article

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