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Arq Bras Cardiol. 2014 May;102(5):489-94. Epub 2014 May 9.

Incidence of ventricular arrhythmias after stem cell therapy in patients with Chagas cardiomyopathy.

[Article in English, Portuguese]

Abstract

BACKGROUND:

Treatment with stem cells in several cardiomyopathies may be related to the increase in arrhythmias.

OBJECTIVES:

To determine whether intracoronary injection of stem cells in patients with Chagas cardiomyopathy is associated with increased incidence of ventricular arrhythmias, compared to the Control Group.

METHODS:

A retrospective cohort study that evaluated the medical records of 60 patients who participated in a previous cross-sectional study. The following data were collected: age, gender, drugs used and Holter variables that demonstrated the presence of arrhythmias. Holter was performed in four stages: randomization, 2, 6 and 12 months segments. The Control Group received medical treatment and intracoronary injection of placebo and the Study Group had drug treatment and autologous stem cell implant.

RESULTS:

There was no difference between Control Group and Study Group when analyzing the arrhythmia criteria. In the intra-group analysis, significant difference was found between the Holter tests of the Study Group for the variable total ventricular premature beats when compared with baseline, with p = 0.014 between Holter at randomization and Holter at 2 months, p = 0.004 between Holter at randomization and Holter at 6 months, and p = 0.014 between Holter at randomization and Holter at 12 months. The variable non-sustained ventricular tachycardia between Holter at randomization and Holter at 6 months showed p = 0.036.

CONCLUSION:

The intracoronary injection of stem cells did not increase the incidence of ventricular arrhythmias in patients with Chagas cardiomyopathy compared to the Control Group.

PMID:
24918914
PMCID:
PMC4051452
DOI:
10.5935/abc.20140053
[Indexed for MEDLINE]
Free PMC Article

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