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Br J Cancer. 2014 Aug 26;111(5):976-80. doi: 10.1038/bjc.2014.294. Epub 2014 Jun 10.

Vitamin D supplements and cancer incidence and mortality: a meta-analysis.

Author information

1
Departments of Nutrition and Epidemiology, Harvard School of Public Health, Building 2, 3rd floor, 655 Huntington Avenue, Boston, MA 02115, USA.
2
1] Departments of Nutrition and Epidemiology, Harvard School of Public Health, Building 2, 3rd floor, 655 Huntington Avenue, Boston, MA 02115, USA [2] Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

BACKGROUND:

Observational studies suggest that effects of vitamin D may be stronger for cancer mortality than for incidence. Yet, existing randomised controlled trials (RCTs) of vitamin D supplementation have limited power to examine the relationships as their primary end points are not cancer incidence or mortality.

METHODS:

Meta-analyses of RCTs of vitamin D supplementation and total cancer incidence and mortality were conducted.

RESULTS:

Over 2-7 years of duration, vitamin D supplementations had little effect on total cancer incidence (400-1100‚ÄČIU per day, summary relative risk (RR)=1.00, 95% confidence interval (CI)=0.94-1.06, I(2)=0%; four RCTs with combined 4333 cases), but significantly reduced total cancer mortality (400-833‚ÄČIU per day, summary RR=0.88, 95% CI=0.78-0.98, I(2)=0%, three RCTs with combined 1190 deaths).

CONCLUSIONS:

Over 2-7 years of duration, the benefit of vitamin D supplementation may be limited to cancer mortality.

PMID:
24918818
PMCID:
PMC4150260
DOI:
10.1038/bjc.2014.294
[Indexed for MEDLINE]
Free PMC Article

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