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Br J Cancer. 2014 Jul 29;111(3):598-602. doi: 10.1038/bjc.2014.309. Epub 2014 Jun 10.

Characterisation of familial colorectal cancer Type X, Lynch syndrome, and non-familial colorectal cancer.

Author information

1
1] Department of Medicine, University of Washington, Seattle, WA, USA [2] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
2
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
3
1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Epidemiology, University of Washington, Seattle, WA, USA.
4
1] Department of Medicine, University of Washington, Seattle, WA, USA [2] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [3] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
5
1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Epidemiology, University of Washington, Seattle, WA, USA [3] Centre for Public Health Research, Massey University, Wellington, New Zealand.
6
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
7
1] University of Melbourne, Parkville, VIC, Australia [2] Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, QLD, Australia.
8
1] Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, QLD, Australia [2] University of Queensland, School of Medicine, Herston, QLD, Australia [3] Envoi Pathology, Herston, QLD, Australia.
9
University of Melbourne, Parkville, VIC, Australia.
10
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
11
Stanford Cancer Institute, Palo Alto, CA, USA.
12
Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
13
University of Hawaii Cancer Center, Honolulu, HI, USA.
14
Department of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA.

Abstract

BACKGROUND:

Familial Colorectal Cancer Type X (FCCTX) is defined as individuals with colorectal cancer (CRC) who families meet Amsterdam Criteria-1 (AC1), but whose tumours are DNA-mismatch-repair-proficient, unlike Lynch syndrome (LS). FCCTX does not have an increased risk of extra-colonic cancers. This analysis compares epidemiologic and clinicopathologic features among FCCTX, LS, and 'non-familial' (non-AC1) CRC cases.

METHODS:

From the Colon Cancer Family Registry, FCCTX (n=173), LS (n=303), and non-AC1 (n=9603) CRC cases were identified. Questionnaire-based epidemiologic information and CRC pathologic features were compared across case groups using polytomous logistic regression.

RESULTS:

Compared with LS, FCCTX cases were less likely to be current (vs never) smokers; have a proximal subsite (vs rectal) tumour; or have mucinous histology, poor differentiation, or tumour-infiltrating lymphocytes. There were no observed differences in co-morbidities or medication usage.

CONCLUSIONS:

FCCTX were less likely to be current tobacco users; other exposures were similar between these groups. Histopathologic differences highly suggestive of LS CRCs do not appear to be shared by FCCTX.

PMID:
24918813
PMCID:
PMC4119982
DOI:
10.1038/bjc.2014.309
[Indexed for MEDLINE]
Free PMC Article

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