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PLoS One. 2014 Jun 11;9(2):e98569. doi: 10.1371/journal.pone.0098569. eCollection 2014.

Discovery and characterization of distinct simian pegiviruses in three wild African Old World monkey species.

Author information

1
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
2
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
3
Makerere University, Kampala, Uganda.
4
Makerere University, Kampala, Uganda; Department of Anthropology and McGill School of Environment, Montreal, Quebec, Canada.
5
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America; Wisconsin National Primate Research Center, Madison, Wisconsin, United States of America.
6
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America; Makerere University, Kampala, Uganda; Wisconsin National Primate Research Center, Madison, Wisconsin, United States of America.
7
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America; Wisconsin National Primate Research Center, Madison, Wisconsin, United States of America.

Abstract

Within the Flaviviridae, the recently designated genus Pegivirus has expanded greatly due to new discoveries in bats, horses, and rodents. Here we report the discovery and characterization of three simian pegiviruses (SPgV) that resemble human pegivirus (HPgV) and infect red colobus monkeys (Procolobus tephrosceles), red-tailed guenons (Cercopithecus ascanius) and an olive baboon (Papio anubis). We have designated these viruses SPgVkrc, SPgVkrtg and SPgVkbab, reflecting their host species' common names, which include reference to their location of origin in Kibale National Park, Uganda. SPgVkrc and SPgVkrtg were detected in 47% (28/60) of red colobus and 42% (5/12) red-tailed guenons, respectively, while SPgVkbab infection was observed in 1 of 23 olive baboons tested. Infections were not associated with any apparent disease, despite the generally high viral loads observed for each variant. These viruses were monophyletic and equally divergent from HPgV and pegiviruses previously identified in chimpanzees (SPgVcpz). Overall, the high degree of conservation of genetic features among the novel SPgVs, HPgV and SPgVcpz suggests conservation of function among these closely related viruses. Our study describes the first primate pegiviruses detected in Old World monkeys, expanding the known genetic diversity and host range of pegiviruses and providing insight into the natural history of this genus.

PMID:
24918769
PMCID:
PMC4053331
DOI:
10.1371/journal.pone.0098569
[Indexed for MEDLINE]
Free PMC Article

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