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Dev Cell. 2014 Jun 9;29(5):501-502. doi: 10.1016/j.devcel.2014.05.017.

LINE-1 of evidence for fetal oocyte attrition by retrotransposon.

Author information

1
Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. Electronic address: schuma@frontier.kyoto-u.ac.jp.

Abstract

Fetal oocytes in mammals undergo extensive apoptosis during development. In this issue of Developmental Cell, Malki et al. (2014) provide insight into how and why such massive oocyte loss occurs through the demonstration that the expression level of LINE-1 retrotransposon defines the survival threshold and thus viability of fetal oocytes.

PMID:
24914555
DOI:
10.1016/j.devcel.2014.05.017
[Indexed for MEDLINE]
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