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World J Gastroenterol. 2014 May 21;20(19):5666-71. doi: 10.3748/wjg.v20.i19.5666.

Reduced genome size of Helicobacter pylori originating from East Asia.

Author information

1
Quan-Jiang Dong, Li-Li Wang, Zi-Bing Tian, Xin-Jun Yu, Sheng-Jiao Jia, Shi-Ying Xuan, Central Laboratories and Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266000, Shandong Province, China.

Abstract

Helicobacter pylori (H. pylori), a major pathogen colonizing the human stomach, shows great genetic variation. Comparative analysis of strains from different H. pylori populations revealed that the genome size of strains from East Asia decreased to 1.60 Mbp, which is significantly smaller than that from Europe or Africa. In parallel with the genome reduction, the number of protein coding genes was decreased, and the guanine-cytosine content was lowered to 38.9%. Elimination of non-essential genes by mutations is likely to be a major cause of the genome reduction. Bacteria with a small genome cost less energy. Thus, H. pylori strains from East Asia may have proliferation and growth advantages over those from Western countries. This could result in enhanced capacity of bacterial spreading. Therefore, the reduced genome size potentially contributes to the high prevalence of H. pylori in East Asia.

KEYWORDS:

Epidemiology; Genome; Helicobacter pylori; Mutation; Recombination

PMID:
24914326
PMCID:
PMC4024775
DOI:
10.3748/wjg.v20.i19.5666
[Indexed for MEDLINE]
Free PMC Article
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