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World J Gastroenterol. 2014 May 21;20(19):5610-24. doi: 10.3748/wjg.v20.i19.5610.

Factors that mediate colonization of the human stomach by Helicobacter pylori.

Author information

1
Ciara Dunne, Brendan Dolan, Marguerite Clyne, School of Medicine and Medical Science and Conway Institute of Biomedical and Biomolecular Science, University College Dublin, Belfield, Dublin 4, Ireland.

Abstract

Helicobacter pylori (H. pylori) colonizes the stomach of humans and causes chronic infection. The majority of bacteria live in the mucus layer overlying the gastric epithelial cells and only a small proportion of bacteria are found interacting with the epithelial cells. The bacteria living in the gastric mucus may act as a reservoir of infection for the underlying cells which is essential for the development of disease. Colonization of gastric mucus is likely to be key to the establishment of chronic infection. How H. pylori manages to colonise and survive in the hostile environment of the human stomach and avoid removal by mucus flow and killing by gastric acid is the subject of this review. We also discuss how bacterial and host factors may together go some way to explaining the susceptibility to colonization and the outcome of infection in different individuals. H. pylori infection of the gastric mucosa has become a paradigm for chronic infection. Understanding of why H. pylori is such a successful pathogen may help us understand how other bacterial species colonise mucosal surfaces and cause disease.

KEYWORDS:

Adhesins; CagA; Colonization; Flagella; Gastric mucosa; Helicobacter pylori; Infection; Polymorphisms; Type IV secretion system; Urease

PMID:
24914320
PMCID:
PMC4024769
DOI:
10.3748/wjg.v20.i19.5610
[Indexed for MEDLINE]
Free PMC Article

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