Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Pathol. 2014 Aug;67(8):697-701. doi: 10.1136/jclinpath-2014-202352. Epub 2014 Jun 9.

MicroRNA as potential biomarker in HCV-associated diffuse large B-cell lymphoma.

Author information

1
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
2
Hematopathology Section, Division of Pathology, Department of Pathophysiology and Transplantation, University of Milan, IRCCS Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy.
3
Division of Pathology, San Paolo Hospital, Milan, Italy.
4
Division of Pathology, A.Manzoni Hospital, Lecco, Italy.
5
Department of Laboratory Medicine, Niguarda Ca' Granda Hospital, Milan, Italy.
6
Division of Pathology, IRCCS Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy.
7
Division of Hematology, Department of Clinical and Community Sciences, University of Milan, IRCCS Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy.
8
Division of Pathology, Department of Pathophysiology and Transplantation, University of Milan, IRCCS Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy.

Abstract

AIMS:

To identify molecular characteristics to hepatitis C virus (HCV)-associated diffuse large B-cell lymphoma (DLBCL) through a comprehensive miRNAs expression profiling.

METHODS:

In this study, miRNA profiles were obtained from 37 patients with DLBCLs and 60 patients with reactive lymph nodes, equally distributed according to HCV presence. Germinal centres, from reactive lymph nodes were used as controls. Clinical features at presentation were available for all patients.

RESULTS:

A set of 52 miRNAs define a signature for HCV-associated DLBCL. Importantly, decreased expression of miR-138-5p and increased expression of miR-147a, miR-147b and miR-511-5p in HCV DLBCL was found to be a poor prognostic factor for HCV-positive DLBCL patients.

CONCLUSIONS:

These data reveal molecular differences in diffuse DLBCL patients according to HCV presence, potentially useful as novel prognostic or therapeutic biomarkers.

KEYWORDS:

HEPATITIS; LYMPHOMA; VIRUS

PMID:
24914240
DOI:
10.1136/jclinpath-2014-202352
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center