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Nat Rev Genet. 2014 Jul;15(7):491-503. doi: 10.1038/nrg3743. Epub 2014 Jun 10.

Transcriptional outcome of telomere signalling.

Author information

1
Emergency Department, Pôle Sino-Français de Recherches en Sciences du Vivant et Génomique, Shanghai Ruijin Hospital, Shanghai 200025, China.
2
Institute for Research on Cancer and Aging, Nice (IRCAN), Nice University, CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice 06107, France.
3
1] Institute for Research on Cancer and Aging, Nice (IRCAN), Nice University, CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice 06107, France. [2] Department of Medical Genetics, Hopital de l'Archet 2, CHU de Nice, BP 3079, 06202 Nice cedex 3, France. [3] Pôle Sino-Français de Recherches en Sciences du Vivant et Génomique, Shanghai Ruijin Hospital, Shanghai 200025, China.

Abstract

Telomeres protect chromosome ends from degradation and inappropriate DNA damage response activation through their association with specific factors. Interestingly, these telomeric factors are able to localize outside telomeric regions, where they can regulate the transcription of genes involved in metabolism, immunity and differentiation. These findings delineate a signalling pathway by which telomeric changes control the ability of their associated factors to regulate transcription. This mechanism is expected to enable a greater diversity of cellular responses that are adapted to specific cell types and telomeric changes, and may therefore represent a pivotal aspect of development, ageing and telomere-mediated diseases.

PMID:
24913665
DOI:
10.1038/nrg3743
[Indexed for MEDLINE]

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