Send to

Choose Destination
See comment in PubMed Commons below
Best Pract Res Clin Gastroenterol. 2014 Jun;28(3):451-63. doi: 10.1016/j.bpg.2014.04.012. Epub 2014 May 5.

Can we get more from our current treatments?

Author information

Department of Gastroenterology, Guy's and St. Thomas' NHS Foundation Trust, Diabetes and Nutritional Sciences Division, King's College London, London, UK. Electronic address:


Crohn's disease is a chronic incurable condition that normally requires lifelong treatment. Whilst the anti-TNF agents have revolutionised the management of Crohn's disease over the last fifteen years, they are not a panacea. In particular, in part due to their immunogenic nature, loss of response limits their long term effectiveness in many patients. The only other long term disease-modifying options are the immunomodulators, methotrexate, azathioprine and mercaptopurine. Therefore, given the limited number of drugs available to treat Crohn's disease, it is important that efforts are made to ensure that drugs are used in the best way possible as once a drug is deemed ineffective, it is rarely used again. For the growing number of patients who have active disease despite having been exposed to all standard therapies, failure to optimise drug therapy may lead to missed opportunities in the management of their disease. In this review, optimisation of drugs commonly used in the management of Crohn's disease will be discussed.


Anti-TNF; Anti-TNF drug levels; Anti-drug antibodies; Azathioprine metabolites; Corticosteroids; Crohn's disease; Methotrexate; Optimising therapy; Thiopurine methyl transferase; Thiopurines

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center