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Rev Alerg Mex. 2013 Oct-Dec;60(4):172-83.

The ocular surface: from physiology to the ocular allergic diseases.

Author information

1
Departamento de Farmacobiología, Centro de Investigaciones Avanzadas, Instituto Politécnico Nacional, México, DF. mcjimenezm@institutodeoftalmologia.org.

Abstract

in English, Spanish

Allergic conjunctivitis (AC) is an inflammation of the conjunctiva secondary to an immune response to exogenous antigens, usually called allergens. In fact, AC is a syndrome that involves the entire ocular surface, including conjunctiva, lids, cornea, and tear film. The signs and symptoms of AC have a meaningful effect on comfort and patient health, and could be influenced by environment, genetics and immune regulation mechanisms, all of which work together in a complex immunological homeostasis. Dysregulation in such immune responses could turn into a variety of ocular allergic diseases (OAD). This review describes some of the current understanding of cellular and molecular pathways involved in different OAD.

KEYWORDS:

Allergic conjunctivitis; CD4+ T cells; Ocular allergic diseases; Tregs

PMID:
24912910
[Indexed for MEDLINE]

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